克罗米酚对成年人低促性腺素性功能减退症有效

洛杉矶（路透社健康版）1月初四日新闻报道：据发表在12月初年出版的《生育与不育》时尚杂志的一项份文件表明克罗米酮类对大部分偏高促官能腺素官能功能减退的男官能病患稳固。来自伯明翰佐治亚大学的该份文件的第一著者Scott J. Whitten芝加哥大学在不能接受路透通讯社美联社时却说：“原发官能或获得官能HH病患在不能接受践踏官能更大和更为比起的病患（例如注射促官能腺激素类）当年同步进行4个月初的克罗米酮类试验官能病患是稳固的。”Whitten芝加哥大学和同僚研究了克罗米酮类对10名HH男官能病患（HH是导致男官能不育的少见因素）是否适当。份文件称作克罗米酮类病患1年后，4名卡尔曼(氏)综合征病患中只有一名病患的精子pH增大而全垂体功能减退症病患的精子缺乏呕吐均不会得到提高。相反，该份文件表明3名未满胃癌的原发官能HH男官能病患经过3个月初克罗米酮类的病患精子pH有了明显增大。目当年为止该组病患已有两名恢复原了子代。Whitten芝加哥大学却说：“除非对克罗米酮类病患不会底物，我们不会因为副作用取消对病患适用该药物。”最终著者总结却说：“因为条件极小，对HH病患促官能腺激素类药物和克罗米酮类的随机研究难以同步进行，然而运用多当年传的严格选择标准对病患同步进行分级似乎借助促使验证克罗米酮类恢复原男官能偏高子代的适当官能。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色想像

编辑： 张靖